On the Geo meridian online travel guide (Geomerid.com) the "South of Spain" region consist of 5 districts that are located in the southern part of Spain from Valencia to Portugal.
The South of Spain includes: Madrid, Castile and La Mancha (Toledo), Extremadura (Merida), Murcia (Murcia), Andalusia (Seville).
The most part of interesting Spanish places for sightseeing are concentrated. Madrid can be considered a starting point for excursions. After visiting the Prado gallery, you should definitely go to the Escorial Palace, as well as the ancient Toledo.
Andalusia has been under Muslim rule for a long time, and there very beautiful architectural style of cities was developed. It combines Arab and European motifs. The most beautiful cities are Granada, Seville, Cordoba, Ronda, and Malaga. Near Granada, you must visit the famous Alhambra Palace. There are a lot of beach resorts in this region.